Putting the Acoustic sim in one of the pre-amp slots is fun if you want to use Parallel path to crossfade, but don't forget Acoustic sim is actually a stereo effect as well! I like it very much in one of the post-amp slots.
I've recorded a very quick and sloppy test with two guitar parts, both my basic Mexican Fender Strat, both with Acoustic sim in X and a compressor in Mod, amp stack disabled. The chords part additionally has the new Delay Widener in the Delay slot.