I'm only using onboard effects/drives, etc. Only external device is the LF controller and expression pedal.
I mostly use a pure boost or fuzz if needed for extra drive. I usually don't go totally clean on too many profiles, keep them on the edge of breakup then back off guitar volume is needs to be cleaner.
On the cleaner profiles i'll use a pure boost and then a green screamer and can stack them both for dual gain stages.
Monitoring via IEMs through the KPA headphone output, mixing in the monitor mix through the KPA Aux inputs.