That sounds pretty painful and cumbersome - having to replace the entire profile in your performances just to change the mic balance.
Maybe easier to separate profiling and speaker miking: do one DI profile of your amp without speaker and create different Impulse Response mixes (with varying levels of the 121) to try with your profile. Now at soundcheck just switch IRs with the same profile until you're happy.
I don't see how that would be easier than taking a number of profiles with same reference amp settings, only difference being the blending.
Spend 5-10 minutes with the band playing in rehearsal to find the best candidate - work on that reference point from home. You don't need to add it to performances before you know what you will ultimately be using.