Thanks for all the tips, I’ll think about it and compare a few options. I tend to prefer open-back headphones because I’ve read they are less fatiguing for the ears and because they sound more spacious. But I guess the main factor for ear fatigue is really the listening volume?
The 'Space' parameter on the PROFILER's Headphone Output is very pleasant and was designed to address ear fatigue when using headphones.
"Space
The “Space” parameter adds a small room simulation to the master signal. This makes listening through headphones far more enjoyable.
A brief explanation: whenever you listen to a sound coming from loudspeakers, you are also hearing the reflections from the floor, the walls and objects around you. Even when you listen to a mono signal, these additional reflections will still result in a stereo image once they reach your ears.
There is only one common situation where no natural reflections happen, and that is when you listen through headphones; as your ears are, biologically speaking, not suited to this, it can quickly lead to listener fatigue. This effect is called “in-the-head localization” and becomes particularly noticeable when you listen to a mono signal.
By using the Space effect, you can add virtual reflections, to create a sense of room and natural space. A mono signal will be converted to a subtle stereo image, which should be far more pleasing to your ears. Even though this effect is designed for headphones, you may also find it appropriate for listening through regular speakers, or for recording. By selecting the option “Space>HeadphOnly”, you can select whether it is applied to the HEADPHONE output only, or to the MAIN OUTPUT as well."