if you want something better than 'amp in the room', put the PROFILER in stereo through a good monitoring system (Studio monitors, wedges, IEM) and add a 1x12 cabinet, preferrably driven by the POWERHEADs internal power amp.
Now you can take advantage of the full profiled sound including cabinet, speaker, mic, EQ etc. for FOH/reheasal room PA/FRFR and the extra impact a 12" speaker delivers, which is what many of us guitar players are used to.
Best of both worlds.
This is exactly how I have my Powerhead connected in my music room/studio.