Stereo loop

I guess, you need to be more specific:

In which module have you placed Loop Stereo? Is it module X or MOD?

"delay is off" is that related to the external effect looped in, or an onboard effect and in which module is it located? Module DLY?

If external, do you switch the external delay off or the effect module at the PROFILER?

"other pedals" are these other effects in the PROFILER and in which module?

Or are these external effects looped in potentially in combination with the external delay?

Just a guess, if this happens in modules DLY and REV the parameter DLY+REV Routing might have an influences, since it determines the signal routing. You find it in Rig Settings.