After several months with my KPA and searching for the right tones, exploring many profiles (including picking up some TAF profiles) I find myself mainly grabbing my Fender American Tele and dialing in the Trainwreck profiles from TAF. These are killer with the Tele! My absolute favorite so far. I find myself playing for hours instead of tweaking. It just sounds so damn good!
I've found what many others have said about certain guitars better for certain profiles. My 335 also works well with the Trainwreck and also the Evil Robot and Blackstar Artisan 15 Profiles from TAF and the Fuchs (Pete Fisher) and the famed Morgan AC20 . My Strat also seems well matched with the TAF Vibroverb and Lindy Fralin profiles.
How fortunate we are as musicians to have so many amazing tools available to us!