what does that even mean?
I don't think the Profiler is the problem here (countless hours of A/B test done by many, many pros in numerous studios etc.)
disable all Stomps and Effects.when you go to 'Profiler' mode and hit 'Next' is the EQ on that page neutral (all zeros)?
when you go to 'Master' on page 4 'Main Output EQ', is that EQ set to neutral (all zeros)?
post an A/B recording of your 5150 and of the profile taken in this same exact setup. reamp if possible.
http://en.wikipedia.org/wiki/Microphonics
Replace microphonic with brittle harsh sounding. No the profiler is not the problem here! It's the operator! That's why I'm here I need help. So anyways, I will check all this and do some recording tests and get back. One thing I forgot to mention is that I'm using an axis guitar. Very high output pickups... not sure if that could contribute, but thought it was worth mentioning.