Right. That's why I'm saying, I get how it works. My question now is, for the DS values, if I increase them to bring them back to zero, I'm assuming I'll then need to go into my gain for that rig and turn it down a bit to get the overall sound/gain back to where it was before I turned up the DS levels, correct? Similarly, with the clean sense changes, if I turn those up or down, then I'll need to adjust the rig volume in the other direction to get everything back to the same overall volume as before, correct?
More or less correct.
I think for clean sens, the answer depends on the rigs in question, since it functions differently (and has a different purpose).
I'd go through the rigs and see the DS value most commonly used (maybe within some suitably small interval, it might not mean a lot in the grand scheme of things), and use that as the overall value for whatever guitar you normally use (lock and save the input section). Then adjust the DS value and gain of the other rigs accordingly. Less work that way.
Then you may still need to look at the CS parameter. use your ears.
By the way, while the DS is an offset to the gain value, they don't use the same scale. So +3 on DS is not the same as +3 on the gain knob, so use your ears here also.