I have a JTV-69 that I use occasionally. My main axe is a Tyler SE. The JTV is awesome for those odd tunings or weird mid song transitions you need to make.
Yesterday, we did a Taylor Swift song where I needed to go between a banjo and regular electric rig.
I use the HD500 as a midi controller for the Kemper. HD500 for most effects and to control the JTV.
One patch is the JTV as a banjo going digitally to the HD500 through spidf to the Kemper input. Kemper using an Avalon pre profile direct to house.
Mid song i change the HD500 patch and it adds delay, switches to the analog pickups, and changes the Kemper to a profile of my 3rd Power amp using the same direct to house di. I just adjust the levels between patches in the Kemper for our FOH guy.
Works amazingly well.