The profiles have been pretty good, but there's something extra people like Michael Britt seem to be getting beyond me.
MAIN IDEAS
MIC TECHNIQUE
Britt has a cool XYZ Table / machine that moves his mic around. So he can sit in the control room and listen to the sound of the mic'ed amp. This lets him get the mic in the perfect spot. On center, off center, 2 inches back, 8 inches back, etc etc etc. So he doesnt have as many bad frequency suckouts from a badly placed mic.
ISOLATION AND ROOM ECHOES
He also has a little room he shoves the cab in, so he cant hear it. This small room may actually hinder his final tone since the room is small. Bigger may be better.
PREAMP AND EQ
The next step might be to put the mic into a preAmp/mixer/etc. So you can tweak it to perfection. Again it helps to have the Amp far away so you cant hear the room sound. Just the EQ'ed sound the Kemper will be seeing.
LESSER IDEAS
EXPANDER
I have also had luck with using an expander gate on the mic. The code the Kemper uses for the tube sim gets compressed really fast. If I use a gate setting of like 1.5:1 I get a better feel out of the profile. Closer to what the real amp feels like. The Kemper may complain a noise gate is in the line but it works fine.
LOWER GAIN
It is also sometimes better to profile the amp at a lower gain than you wish to have in the profile. This sometimes helps the Kemper figure out the tube/gain characteristics better.
LESS AMP SAG FROM VOLUME
It may also be good to try and profile at a lower volume and then adjust the amp sagging value in the Kemper. The whole point of the Kemper is to NOT do this. But it is worth a try.
ROOM EQ WIZARD
If you have a PC nearby you can download REW and then you can sweep the amp and mic setup. Then you can visually see if there are bad frequency suckouts from room echoes and mic placement. First time I tried this with a 2x12" cab I was blown away by how much the unused speaker was bleeding in and screwing up the response. Covered it up with blankets, etc and things got much better all of a sudden.
DIRECT BOX AND IR/CABS
You can also try using a direct box and profile the amp with "NO CABINET" selected. Then add a cab or IR later. This gets rid of the mic placement issue assuming the person who made the IRs was good