I have 4 basic tones:
Hard rock Marshall with humbuckers
Low gain crunch with humbucker split
Clean tone with humbucker split
Ultra clean tone with neck humbucker split
I go from Twisted Sister to KC and The Sunshine Band to Duran Duran all night.
The thing that changes for me is effects.
I have the amen4 basic core tones, but have performance banks for different songs that require more detailed tones.
Like Are You Gonna Go My Way by Lenny Kravitz- I do the flange part before the solo and have a rig dedicated for that song.
Or U2 Streets Have No Name with the delay.