We use a fully isolated IEM mix, direct gtrs/bass, mics split, everything goes into a MOTU 828mk3, 5 separate stereo mixes, sennheiser wireless, all controllable from an iphone/ipad. We use custom IEMs, mine are 4 drivers. Best low end I have ever heard. The MOTU has internal DSP (EQ, comp, verb) but will be upgrading to the behringer x32 rack when that finally comes out. Kemper, axefx, and a gsp1101. Everything changes via MIDI
We made the choice after this terrible sound guy almost fucked our hearing. A little louder does not mean 10db. With no amps, cabs, etc to move and setup, setup time is comparably the same. All gtr/bass stuff sits in one 12u that is super light, then drummer has a rack with all the computer stuff.
We are going to snake everything together with DB25 connections so setup will be lightning fast. Run power, two cables... uh... make sure guitar is tuned? That quick.
It takes time to 'learn' to love the dry sound. It's awkward at first but in the mix it isn't so bad. For those who have that mushy problem, if you can control eq, everything has too much low mids, sub lows, etc.