In other words: pickup A into amp with preamp gain at 8/10 and particular settings may sound great. But hot pickup B into the same set up -- real SET up -- may push the amp in a relatively different way. It's not even just about "distortion level", at that point, imo, but other meaningfully separate tonal characteristics. Of course this depends on how the amp works and how we construct our concepts.
Now if the profile is ideally faithful to the "amp at that setting" and reacts much he same way, it should reflect the "poop" tone you'd get with the hot pickup into the real source tone at the profiled settings. But... reducing distortion sens, at that point, would reduce distortion level while these other, meaningfully-separate-from-distortion characteristics will still be retained on some level.
And these may not work in your favor.
Then again, it's also possible that you like how the profile (WITH kemper gain/distortion sens reduced) of amp at 10/10 sounds like compared to real amp tone at 7/10 or profile of that setting, considering you'd be maintaining some of the "character" of the amp at the higher preamp level, but ending up with less distortion... In fact, I've had quite a few cases like this myself.
But imo this can be more complex when pickups are quite different, relatively speaking For me, all the more reason to profile amps. And surely I think the above can be relevant in the whole "what kemper's missing" discussion in terms of narrowing down things.