Over the years, I have grown to love the sound of the mic'ed tube amp sound and the "amp-in-the-room" is now piercing and unpleasant in comparison.
Well said. And if your purpose as a guitar player is to serve the song and the bands performance it is the only way to go.
Things are getting funny when guitar players want a "sound in the room" just like their hero guitar player - as they know it from records. Well, on records they are hearing miced amps. With the low end cut by the mix engineer to keep space for the bass player etc etc
My two cents for guitar sounds for song-serving:
Get yourself a regular PA - which is as FRFR as it gets. Could well be a mini PA like from LD Systems for about 500 bucks. Or some JBL EONs. For moddest SPL a pair of active studio monitors will do the trick. Connect an MP3-Player to the Profiler and the Profiler to that PA (or the studio monitors). Now listen to your favorite songs and mixes. Play with the EQ in the Profilers output section. Do only cuts, no boosts. On many speakers I have to cut Treble by say 2 dB - maybe I am allergic to crossover distortion between mids and highs... And I high pass below say 45 Hz. The goal is to make your favorite songs sound clear and transparent and pleasant for you. Double check again and again with the most neutral pair of headphones you can grab.
Only AFTER you achieved that kind of reference you can start selecting and fine tuning your profiles of choice. Always fine tune the amp while playing and listening to a well mixed backing track (with the same and consistent loudness level). This is important for your amp loudness as well as the tonal balance within a song context. Do this for every rig you intend to use. The backing track is a permanent reference for your ears. Otherwise they will drift over time and dont serve you well for judging...
Apropos fine tuning: Even though we got liquid profiling now consider start tuning with the great and unique profiler amp parameters first!
If you want more vintage - silky - smooth sounds try lowering definition or clarity and pick. Increase power sag. For modern and punchy metal sounds do the opposite. And only after that reach out for good old bass - mid -treble - presence. knobs. Yes, its the 21. century...
This procedure will reward you with instantly OK guitar sounds on any stage or rehearsal room or studio. And most song recordings for that matter. From here its an ease for the sound engineer to make your guitar sound excellent in that particular venue with that particular PA or song context.
BTW:
I got a sound proof live room in my basement with a stereo pair of 12 inch JBL EONs plus the 18 inch subwoofer. Max SPL is well above 125 dB. There is no problem to "emulate" a Marshall Plexi full stack. Sounds earth shaking without changing the profiles or rigs. And no ordinary listener could tell its not a "Real Stack". Its great "amp in the room" AND song serving sound at the same time.