Hello,
I'm actually having the same issue! I worked late into the night last night organizing Rig Manager and testing profiles. Everything worked fine. This morning I power everything up RM and the Profiler do not see each other at all! Tried different USB cables, different ports, updated Kemper to new firmware....
The Audio/Midi detection on my Mac doesn't see the Kemper either. It was all working flawlessly last night!