I have Mesa Two Ninety, running stereo to an Egnater cab (4 X 12 celestion Vintage 30`s speakers). It sounds amazing both with KPA or AXE FXII. But a lot better with KPA, in my opinion and considering I play 7 string guitar mostly, and metal/rock stuff. I also sounds really great on another amp I have, that is the Line 6 Spider Valve, a Bogner project, and, to be honest, I even prefer using the line 6. I run mono on Line 6 and it has 1 vintage 30s speaker only. But really loud. Also, I tried with my old buddy Rocktron Velocity 120, solid state power amp, that I have for more than 10 years and used a lot together with Marshall JMP1. Not good at all, compared to those valve power amps. And I used those same cabs above (Egnater and Line 6 ones).
The problem I see with Mesa is that it is TOO heavy and takes some 30 min for the valves to get to the point. With Line 6, I don`t take that care, it is lighter even with the cab and it is MUCH cheaper.
Maybe the Line 6 Spider Valve with two speakers (212, I guess), would be perfect. Mesa is really heavy, big and I tend to not play with it at all. Line 6 valve gives me the power I need and sounds just amazing.
Hope it is not too late for the answer and that helps you.