I've never had a profile that didn't need refining.
Your issue sounds like there is something wrong with your routing setup. Could you post a breakdown of the full rig? Are you going through any digital gear when profiling? Any soundcards or pedals or anything that could introduce latency into the chain?
The refining process doesn't respond well when there is latency built into the system. So when making profiles, you should always strip the entire setup back to the most basic approach - guitar into kemper, direct send into the amp (a drive pedal can be put here too) and then amp into a loadbox or a speaker cab, and then a microphone feed or a loadbox feed into the return on the Kemper.
If you introduce mixers and other bits of gear, you're introducing more room for error.