Maybe it is just me (I deal with a lot of noise at home with most gear), but I noticed some noise on some rigs that seem to be related to the pick parameter. When I center the pick parameter at 0 the noise goes away, if I move off of that it comes back.
I am not sure if it is aliasing, but when I pick the low E string hard you would hear some odd hash/fuzz come and go around the note. It was not clipping, tried different guitars, different cables.
For now I just edited all those rigs to have pick set at zero when I hear it and that reduced the noise for me. Not sure if it would help anyone else but thought I would mention it.