Depends on the profile of course but I've noticed that bumping the gain adds undesirable fizziness to tones rather than what I would have expected on my tube amps of the past (Dr Z, Marshall, HiWatt, Fender, others). Then I noticed in a couple of "Tips" lists from what seem like knowledgeable Kemper-world sources that this was discouraged in favor of just finding a higher-gain profile or using OD pedal presets.
Have you tried with liquid profiles?