Will we ever hear it in the mix? No. Will we hear it as tone chasers? Probably. Will an audience ever care? Absolutely not.
I certainly would not understand what would be more important than if you could not tell it in the mix and if the audience would ever care. Really, if the audience can't hear the difference what's the fuss? I think the goal of many musicians is to make music that people like and want to make you a rock star over or at least money. They couldn't care less if you have the latest quad neuralizer or whatever.
Like I always say how much better can it get than sounding and feeling exactly like the app that's profiling? A proper profile will do exactly that and I proved it so many times to meticulous ears and tube amp snobs it's ridiculous .
My opinion: It's really just that people can't stand having the same old thing for a long time and have to have the latest greatest so they have something to talk about on the forums. Nobody wants to talk about your Fender hot rod deluxe or Kemper I anymore, they wanna talk about how their new nuroverb myplex custom, or the nutrix biomec is so much better and how the big new touch screen on it is wonderful or whatever. Anything the majority of people don't have everybody likes to say is the best thing ever. Similar to people that love to run out, wait in line to see the new movie that's out before anybody else does. Then they get to say "yeah I saw it".(comparable in context to been there done that) also like: "Yeah I played a Fender hot rod deluxe and a Kemper one".
I think with a lot of all these new modelers people try to get you to buy what they did by making it sound so good so they don't feel all alone in buying one & want to convince you to join the club, only to leave yout behind when the next new Dervish Whirlwind MKIII comes out and that's the thing you should get.