Or is it just a myth with this famous "Amp in a room"? After all - it is not the amp, which the profiler can replicate very well, and most of you agree with. It is the sound coming out of a box - whatever the box type is. And then: it is the "room", which can be a very different thing. Further: the surrounding sounds: at home alone or with an (extremely?) loud band (which instruments take part?) So many factors, and of course your ears or subjective factor.
Or is it the problem that guitarrists are never really satisfied with their sound (instrument, effects, amp, cabs, etc).
Good point. That's not really what I was describing, and I'm generally pretty happy with my tone though.