I think the selectable/adjustable mics in the cabinet section of the QC will take the place of controls like Definition and Clarity i the Amp block, and Low/High shift in the Cab block.
most of all QC ir's if not all are done by Nolly, if you dont like how Nolly's ir's sound/voicing then you will be out of luck with this feature. Those ir's sound good for modern metal, but im not sure if i would'v used them for anything else personally, thats 100% up to taste though.
Thats being said there are other third party ir loaders that can do the same, tweak it on your pc once you dial the sound you want - export the ir file and load into any dsp/vst you want.